Prozac (10 mg | 20mg)
Best Price $0.33Per pill

Active Ingredient: Fluoxetine

Prozac is a type of antidepressant known as an SSRI. It is often used to treat depression, and also sometimes obsessive compulsive disorder and bulimia.

Brands: Prozac Weekly, Sarafem, and Prozac
Pregnancy: Consult a doctor
Alcohol: Interactions can occur

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Dr. Konstantin Nikiforov Content Administrator Updated on: 30/11/2020

What is Prozac?

Fluoxetine belongs to the group of antidepressants. It is produced by a Russian pharmaceutical company in contrast to its foreign counterpart – Prozac. The latter is the brainchild of the British pharmaceutical Corporation. Therefore, it costs an order of magnitude more expensive, and its effectiveness is comparable to the domestic drug.

How does Fluoxetine work?

Fluoxetine (Prozac) blocks the reverse flow of serotonin to neuronal synapses (places where nerve cells connect). As a result, the content of this mediator (a substance involved in the transmission of nerve impulses) in the connective elements increases significantly, so for a long time, it manages to affect the postsynaptic regions, causing characteristic changes. This is manifested by:

  • Stimulating effect on the nervous system;
  • Improved mood;
  • Activation of mental processes;
  • Suppression of anxiety and anxiety;
  • Reduced appetite, ultimately leading to weight loss.

In addition to inhibiting serotonin uptake in the nervous tissue, Fluoxetine similarly affects platelets, reducing their aggregation (bonding) ability. This positive effect helps prevent thrombosis in patients at risk. But as the main therapeutic effect, this property is not used, it is a "pleasant" addition to antipsychotic effects.

An important advantage of this antidepressant is the lack of sedation. Therefore, Fluoxetine (Prozac) can be used by people engaged in precision work that requires care:

  • Drivers;
  • Jewelers;
  • Aviation industry, etc.

Pharmacological profile

Prozac is a selective serotonin reuptake inhibitor, belongs to the group of third-generation antidepressants, and is used for the treatment of depressive, anxiety, and panic disorders (in the complex therapy). The pharmacological effect of the drug is based on an increase in the concentration of serotonin – the "happiness hormone" in the brain, which increases its effect on the nervous system. Prozac has a strong antidepressant effect and reduces anxiety, nervous tension, and fear.

The structural formula of Fluoxetine

It also treats dysphoria – a very low mood, which is characterized by strong irritability and hostility to others, sometimes bordering on aggression. Also, the medication does not negatively affect the heart, does not have a sedative effect, and does not cause an excessive decrease in blood pressure when taking an upright position.

It is well absorbed by the body. The optimal concentration of the drug in the blood plasma is reached at 2-3 weeks of administration. It is almost completely excreted by the kidneys. It is also excreted in breast milk in an amount of up to 25% of the total concentration in the blood. The therapeutic effect of Prozac is due to its mechanism of action, which is aimed at suppressing the reuptake of serotonin.

Thus, the concentration of the neurotransmitter in the synapse increases, and its effect is enhanced and prolonged. The medication improves mood and stimulates the nervous system, helps to overcome obsessive thoughts and nervous breakdown, removes feelings of anxiety and fear, and reduces appetite. It does not have a sedative effect and does not cause drowsiness.

Prozac is a drug that has antidepressant properties. It stabilizes the nervous system and improves the general condition of the patient. After passing a full therapeutic course, the lack of serotonin is restored. This substance is necessary for the transmission of nerve impulses.

Mechanism of action

Prozac slows down the serotonin uptake. The active substance does not react with other compounds. This indicates that the drug does not interact with cholinergic, adrenergic, histamine, and dopaminergic receptors.

Antidepressants affect the levels of serotonin. Due to this, dysphoria is relieved, fear, anxiety, and tension are removed. The active ingredient does not affect the work of the myocardium. It should be noted that there is no sedative activity. The risk of orthostatic hypotension is minimal.

Prozac can only be prescribed by the attending physician. The drug has a long-lasting effect. The maximum concentration of the active substance in the patient's blood is fixed 7-8 hours after taking a single norm. The medication is allowed to drink both once and during the course. The medicinal composition is excreted through the urinary system.


The active components of the drug are fluoxetine hydrochloride. Additional substances include Dimethicone and starch. The shell contains the following components: patent dye, yellow iron oxide, and titanium dioxide.


Prozac is characterized by relative safety. However, it is strictly forbidden to take it for minor patients, persons with a history of hypersensitivity to the ingredients of the composition.

Special care should be taken when prescribing an antidepressant to patients with suicidal tendencies. Factors that aggravate this condition include severe depression and sleep problems. Among the relative contraindications are old age, diabetes, epilepsy, liver, and kidney diseases. Absolute include glaucoma, convulsive syndrome, benign prostatic hyperplasia. Expressed psychomotor agitation can provoke the development of negative manifestations.

Pregnant women have been prescribed the drug if the intended benefit is greater than the possible risk. If the capsules were prescribed to a woman in the last months of pregnancy, the doctor should regularly monitor the condition of the fetus, and subsequently the newborn child. This is because fluoxetine penetrates the placental barrier and into breast milk.

Form release

Prozac is sold in the form of solid gelatin capsules. They can have a cream or green color. Inside the pill is a white powder. Capsules are packed in blister packs. In one cardboard pack, there are 2 plates (28 pills).

Indications for use

The drug is prescribed to people suffering from the following pathologies:

  • bulimia, occurring in the nervous system;
  • dystrophic disorder;
  • depression;
  • obsessive-compulsive disorder;
  • alcoholism;
  • addiction.

Unreasonable anxiety and nervous overeating become a significant cause for concern. If signs of malaise appear, the patient should immediately contact a doctor.

The order of application

Prozac is used orally. Capsules are taken whole, their shell should not be damaged. The drug is washed down with a sufficient amount of liquid. Juices, tea, coffee, and soda will not work. Prozac is allowed to be taken both before and after meals. The daily dosage depends on the diagnosis:

  • depression-20 mg;
  • bulimia nervosa-60 mg;
  • compulsive disorders - from 20 to 60 mg.

The standard dosage is adjusted based on the patient's well-being and individual characteristics. Start taking Prozac should be after the course of MAO inhibitors is completed.

Side effect

An antidepressant, like other medications, can cause abnormalities in vital systems:

  • Cardiovascular – jumps in blood pressure, hot flashes, vasculitis.
  • Digestive tract-dyspepsia, stool disorders, changes in taste sensations, dryness of the mucous membranes.
  • CNS – severe headaches, nightmares, unreasonable anxiety, the appearance of seizures.
  • Urogenital – sexual impotence, dysuria, bleeding in the genital tract.

The patient may have reduced vision, develop psychomotor hyperactivity, myoclonus, hypomania. There may be an allergic reaction, it is expressed in the form of skin rashes, anaphylactic shock, Quincke edema, excessive sweating.

The risk of side effects is reduced if the patient follows the doctor's recommendations and the manufacturer's instructions during treatment. If the prescribed dosage is exceeded, ventricular tachyarrhythmia, pyrexia, stupor, and hypotension occur. To eliminate the malaise, the patient is prescribed symptomatic therapy.

To prevent deterioration of General health, it is necessary to observe the nuances prescribed by the instructions for use. In the treatment of elderly people, the daily rate must be adjusted. Patients in this age group have many chronic diseases. The drug regimen includes medications that belong to different pharmacological groups. Therefore, when prescribing therapy, it is necessary to take into account the interaction of this medication with other drugs.

Taking Prozac is strictly forbidden to combine with the use of alcoholic beverages.

You should also limit the time spent behind the wheel and in the workplace. The drug harms the ability to concentrate. The rate of psychomotor reactions decreases.


If there are contraindications to taking Prozac (or Generic Prozac), it is replaced with the following medications:

  • Fluoxetine;
  • Prodep;
  • Bioxetin;
  • Darton;
  • Deprex.

This list is complemented with a Portal, Proflusak, Ramexam, and Plovilom. Among the complete analogs, Floxet and Fluoxetine-nicomed are distinguished.

Storage conditions of the drug

Prozac is kept in its original packaging. The storage temperature should not exceed 30 degrees Celsius. Shelf life-3 years, the date of manufacture is indicated on the cardboard package. The medication can only be purchased with a prescription from your doctor.

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